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stimulates the expression of galectin-9 in cultured human endothelial cells
Departments of
* Vascular Biology,
Molecular Biology, Institute of Brain Science,
Pathology,
# Dentistry and Oral Surgery,
** the Second Department of Internal Medicine, and
Dermatology, Hirosaki University School of Medicine, Japan; and Departments of
Immunology and Immunopathology and
|| Endocrinology, Kagawa Medical School, Japan
Correspondence: Tadaatsu Imaizumi, M.D., Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan. E-mail: timaizum{at}cc.hirosaki-u.ac.jp
Galectin-9 is a member of the galectin family and has been identified
as an eosinophil chemoattractant produced by activated T lymphocytes.
Vascular endothelial cells play an important role in the initial step
of eosinophil recruitment and activation in immune and inflammatory
responses. We have addressed the stimulation of galectin-9 expression
in endothelial cells. Galectin-9 was detected in membrane and cytosolic
fractions of human umbilical vein endothelial cells stimulated with
interferon-
(IFN-). IFN- also enhanced the adhesion of human
eosinophilic leukemia-1 cells to endothelial monolayers, and it was
inhibited by the presence of lactose. Interleukin-4, which induces
eotaxin expression, did not affect the expression of galectin-9. The in
situ endothelium from patients with inflammatory diseases was found to
express galectin-9. IFN--induced production of galectin-9 by
endothelial cells may play an important role in immune responses by
regulating interactions between the vascular wall and
eosinophils.
Key Words: eosinophils • adhesion • cytokine
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