Accuri C6 Flow Cytometer System
Originally published online as doi:10.1189/jlb.0209103 on August 12, 2009

Published online before print August 12, 2009
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(Journal of Leukocyte Biology. 2009;86:1125-1134.)
© 2009 Society for Leukocyte Biology

Brewing complications: the effect of acute ethanol exposure on wound healing

Katherine A. Radek*, Matthew J. Ranzer{dagger} and Luisa A. DiPietro{dagger},1

* Department of Medicine, Division of Dermatology, University of California at San Diego, La Jolla, California, USA; and
{dagger} Center for Wound Healing and Tissue Regeneration, University of Illinois at Chicago, Chicago, Illinois, USA

1. Correspondence: Center for Wound Healing and Tissue Regeneration, University of Illinois at Chicago (MC 859), 801 S. Paulina, Room 401B, Chicago, IL 60612-7211, USA. E-mail: ldipiet{at}uic.edu

ABSTRACT

Ethanol consumption is linked to a higher incidence of traumatic wounds and increases the risk for morbidity and mortality following surgical or traumatic injury. One of the most profound effects of acute ethanol exposure on wound healing occurs during the inflammatory response, and altered cytokine production is a primary component. Acute ethanol exposure also impairs the proliferative response during healing, causing delays in epithelial coverage, collagen synthesis, and blood vessel regrowth. The accumulated data support the paradigm that acute ethanol intoxication prior to injury significantly diminishes a patient’s ability to heal efficiently.

Key Words: alcohol dehydrogenase • extracellular matrix • endothelial growth factor • alcohol • injury • trauma