| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
Published online before print May 12, 2006
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Article |
School of Biochemistry and Immunology, Trinity College Dublin, Ireland
@ To whom correspondence should be addressed. E-mail: miggins{at}tcd.ie.
 |
Abstract |
|---|
Toll-like receptor (TLR) activation is dictated by a number of factors including the ligand itself and the localization of the receptor, in terms of expression profile and subcellular localization and the signal transduction pathway that has been activated. Recent work into TLR signal transduction has revealed complex regulation at a number of different levels including regulation by phosphorylation, targeted degradation, and sequestration of signaling molecules. Here, we describe recent advances that have been made in our understanding of how TLR signaling is regulated at the biochemical level.
Key Words: inflammation • regulatory molecules
This article has been cited by other articles:
|
|
 |
|
  J. P. Nicola, M. L. Velez, A. M. Lucero, L. Fozzatti, C. G. Pellizas, and A. M. Masini-Repiso Functional Toll-Like Receptor 4 Conferring Lipopolysaccharide Responsiveness Is Expressed in Thyroid Cells Endocrinology, January 1, 2009; 150(1): 500 - 508. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-C. Maa, M. Y. Chang, Y.-J. Chen, C.-H. Lin, C. J. Yu, Y. L. Yang, J. Li, P.-R. Chen, C.-H. Tang, H.-Y. Lei, et al. Requirement of Inducible Nitric-oxide Synthase in Lipopolysaccharide-mediated Src Induction and Macrophage Migration J. Biol. Chem., November 14, 2008; 283(46): 31408 - 31416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Faisal, A. Saurin, B. Gregory, B. Foxwell, and P. J. Parker The Scaffold MyD88 Acts to Couple Protein Kinase C{epsilon} to Toll-like Receptors J. Biol. Chem., July 4, 2008; 283(27): 18591 - 18600. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. J. Yoon, S.-B. Jeon, I.-H. Kim, and E. J. Park Regulation of TLR2 Expression by Prostaglandins in Brain Glia J. Immunol., June 15, 2008; 180(12): 8400 - 8409. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Ovstebo, O. K. Olstad, B. Brusletto, A. S. Moller, A. Aase, K. B. F. Haug, P. Brandtzaeg, and P. Kierulf Identification of Genes Particularly Sensitive to Lipopolysaccharide (LPS) in Human Monocytes Induced by Wild-Type versus LPS-Deficient Neisseria meningitidis Strains Infect. Immun., June 1, 2008; 76(6): 2685 - 2695. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Tomchuck, K. J. Zwezdaryk, S. B. Coffelt, R. S. Waterman, E. S. Danka, and A. B. Scandurro Toll-Like Receptors on Human Mesenchymal Stem Cells Drive Their Migration and Immunomodulating Responses Stem Cells, January 1, 2008; 26(1): 99 - 107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Chen, M. J. Cowan, J. D. Hasday, S. N. Vogel, and A. E. Medvedev Tobacco Smoking Inhibits Expression of Proinflammatory Cytokines and Activation of IL-1R-Associated Kinase, p38, and NF-{kappa}B in Alveolar Macrophages Stimulated with TLR2 and TLR4 Agonists J. Immunol., November 1, 2007; 179(9): 6097 - 6106. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-K. Lee, S. J. Brown, H. Rosen, and P. S. Tobias Application of beta-Lactamase Enzyme Complementation to the High-Throughput Screening of Toll-Like Receptor Signaling Inhibitors Mol. Pharmacol., October 1, 2007; 72(4): 868 - 875. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. MacLeod and L. M. Wetzler T Cell Activation by TLRs: A Role for TLRs in the Adaptive Immune Response Sci. Signal., September 4, 2007; 2007(402): pe48 - pe48. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Yamamoto, S. Uematsu, T. Okamoto, Y. Matsuura, S. Sato, H. Kumar, T. Satoh, T. Saitoh, K. Takeda, K. J. Ishii, et al. Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency J. Exp. Med., September 3, 2007; 204(9): 2233 - 2239. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. J. Sheedy and L. A. J. O'Neill The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling J. Leukoc. Biol., August 1, 2007; 82(2): 196 - 203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Hu, J. Chen, L. Wang, and L. B. Ivashkiv Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways in macrophage activation J. Leukoc. Biol., August 1, 2007; 82(2): 237 - 243. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Wang, T. Chen, C. Han, D. He, H. Liu, H. An, Z. Cai, and X. Cao Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4 Blood, August 1, 2007; 110(3): 962 - 971. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Khan, M. S. Bijker, J. J. Weterings, H. J. Tanke, G. J. Adema, T. van Hall, J. W. Drijfhout, C. J. M. Melief, H. S. Overkleeft, G. A. van der Marel, et al. Distinct Uptake Mechanisms but Similar Intracellular Processing of Two Different Toll-like Receptor Ligand-Peptide Conjugates in Dendritic Cells J. Biol. Chem., July 20, 2007; 282(29): 21145 - 21159. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Miggin, E. Palsson-McDermott, A. Dunne, C. Jefferies, E. Pinteaux, K. Banahan, C. Murphy, P. Moynagh, M. Yamamoto, S. Akira, et al. NF-{kappa}B activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1 PNAS, February 27, 2007; 104(9): 3372 - 3377. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Szabo, A. Dolganiuc, Q. Dai, and S. B. Pruett TLR4, Ethanol, and Lipid Rafts: A New Mechanism of Ethanol Action with Implications for other Receptor-Mediated Effects J. Immunol., February 1, 2007; 178(3): 1243 - 1249. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
