Other Issues:	Contents: August 2009, Volume 86, Issue 2   [Index by Author]  [Cover Caption] Editorials Pivotal Advance Spotlight on Leading Edge Research Reviews Cell Development, Differentiation, & Trafficking Receptors, Signal Transduction, & Genes Inflammation, Extracellular Mediators, & Effector Molecules Host Defense & Pathophysiology Systems Biology & Immunogenetics Consulting Editors
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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF)

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Editorials

Zhangguo Chen, Lanfen Chen, and Richard S. Blumberg Editorial: CEACAM1: fine-tuned for fine-tuning J Leukoc Biol 2009 86: 195–197 . [Full Text] [PDF]

H. Shaw Warren Editorial: Mouse models to study sepsis syndrome in humans J Leukoc Biol 2009 86: 199–201 . [Full Text] [PDF]

Mitchell P. Fink Editorial: Hemopexin: newest member of the anti-inflammatory mediator club The iron-binding protein, hemopexin, down-regulates the production of proinflammatory mediators by immunostimulated-macrophages or monocytes. J Leukoc Biol 2009 86: 203–204 . [Full Text] [PDF]

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Pivotal Advance

Elizabeth O. Lobo, Zhifang Zhang, and John E. Shively Pivotal Advance: CEACAM1 is a negative coreceptor for the B cell receptor and promotes CD19-mediated adhesion of B cells in a PI3K-dependent manner CEACAM1 coreceptor for the B-cell receptor inhibits activated B-cells by recruiting SHP-1 to its phosphorylated ITIMs, preventing phosphorylation of the large subunit of PI-3K. J Leukoc Biol 2009 86: 205–218 . [Abstract] [Full Text] [PDF]

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Spotlight on Leading Edge Research

Jacqueline Unsinger, Jacquelyn S. McDonough, Leonard D. Shultz, Thomas A. Ferguson, and Richard S. Hotchkiss Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice Sepsis in mice possessing a functional human immune system causes extensive apoptotic death of human immune effector cells and increases in both pro- and anti-inflammatory human cytokines. J Leukoc Biol 2009 86: 219–227 . [Abstract] [Full Text] [PDF]

Xueya Liang, Tian Lin, Guangjie Sun, Laura Beasley-Topliffe, Jean-Marc Cavaillon, and H. Shaw Warren Hemopexin down-regulates LPS-induced proinflammatory cytokines from macrophages The heme-binding protein hemopexin limits TLR4 and TLR2 agonist-induced macrophage cytokine production through a mechanism distinct from heme oxygenase-1. J Leukoc Biol 2009 86: 229–235 . [Abstract] [Full Text] [PDF]

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Reviews

Christian R. Geest and Paul J. Coffer MAPK signaling pathways in the regulation of hematopoiesis Relevance of mitogen-activated protein kinases ERK, JNK, and p38 in the regulation of myeloid differentiation. J Leukoc Biol 2009 86: 237–250 . [Abstract] [Full Text] [PDF]

Derrick Gibbings and A. Dean Befus CD4 and CD8: an inside-out coreceptor model for innate immune cells CD4 and CD8 enhancement of FcR-like signaling is discussed as a potential role when expressed by innate immune cells. J Leukoc Biol 2009 86: 251–259 . [Abstract] [Full Text] [PDF]

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Cell Development, Differentiation, & Trafficking

L. Giordani, M. Sanchez, I. Libri, M. G. Quaranta, B. Mattioli, and M. Viora IFN- amplifies human naïve B cell TLR-9-mediated activation and Ig production CpG ODN drives B cells to differentiate into plasma cells; IFN- amplifies the inductive effect of CpG ODN on B cells. J Leukoc Biol 2009 86: 261–271 . [Abstract] [Full Text] [PDF]

Yu-Hwa Huang, Alla L. Zozulya, Christian Weidenfeller, Nicholas Schwab, and Heinz Wiendl T cell suppression by naturally occurring HLA-G-expressing regulatory CD4+ T cells is IL-10-dependent and reversible HLA-Gpos Treg-mediated suppression is critically dependent on the secretion of IL-10 but not TGF-β. J Leukoc Biol 2009 86: 273–281 . [Abstract] [Full Text] [PDF] [Supplemental Figure S1]

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Receptors, Signal Transduction, & Genes

Mabel M. P. Chan, Benny K. W. Cheung, James C. B. Li, Lally L. Y. Chan, and Allan S. Y. Lau A role for glycogen synthase kinase-3 in antagonizing mycobacterial immune evasion by negatively regulating IL-10 induction GSK3 regulation of inflammation is targeted by mycobacterial for evasion of immunity resulting in IL-10 induction in the host. J Leukoc Biol 2009 86: 283–291 . [Abstract] [Full Text] [PDF]

William J. Housley, Catherine A. O'Conor, Frank Nichols, Lynn Puddington, Elizabeth G. Lingenheld, Li Zhu, and Robert B. Clark PPAR regulates retinoic acid-mediated DC induction of Tregs PPAR plays a significant role in the induction of regulatory T cells (Tregs) by DC and can mediate enhanced conversion via secretion of retinoic acid. J Leukoc Biol 2009 86: 293–301 . [Abstract] [Full Text] [PDF]

Joanna Shoenfelt, Robert J. Mitkus, Rolf Zeisler, Rabia O. Spatz, Jan Powell, Matthew J. Fenton, Katherine A. Squibb, and Andrei E. Medvedev Involvement of TLR2 and TLR4 in inflammatory immune responses induced by fine and coarse ambient air particulate matter Fine and coarse air pollution particles signal macrophage activation via differential utilization of Toll-like receptors (TLR) 2 and TLR4 but shared use of the MyD88 signaling pathway. J Leukoc Biol 2009 86: 303–312 . [Abstract] [Full Text] [PDF]

Susan Ishmael and Donald MacGlashan, Jr. Early signal protein expression profiles in basophils: a population study Despite a broad range of functional responses through FceRI, there is limited variation of early signaling elements in basophils. J Leukoc Biol 2009 86: 313–325 . [Abstract] [Full Text] [PDF]

Lena Svensson, Elin Redvall, Marianne Johnsson, Anna-Lena Stenfeldt, Claes Dahlgren, and Christine Wennerås Interplay between signaling via the formyl peptide receptor (FPR) and chemokine receptor 3 (CCR3) in human eosinophils Signals by the formyl peptide receptor (FPR) cause unidirectional down-regulation of the chemokine receptor CCR3-mediated chemotaxis but not respiratory burst in human eosinophils. J Leukoc Biol 2009 86: 327–336 . [Abstract] [Full Text] [PDF]

Tolunay B. Aydemir, Juan P. Liuzzi, Steve McClellan, and Robert J. Cousins Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN- expression in activated human T cells Dietary zinc supplement increases production of the tumor/infection-fighting cytokine IFN- in T cells by increasing zinc transport from the lysosomes to the cell cytoplasm. J Leukoc Biol 2009 86: 337–348 . [Abstract] [Full Text] [PDF]

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Inflammation, Extracellular Mediators, & Effector Molecules

Kwang Soo Kim, Ji-Young Park, Ilo Jou, and Sang Myun Park Functional implication of BAFF synthesis and release in gangliosides-stimulated microglia BAFF and BAFF receptors, which are expressed in microglia, may play an important role in CNS inflammation. J Leukoc Biol 2009 86: 349–359 . [Abstract] [Full Text] [PDF]

Hui Wan, Jojanneke M. C. Coppens, Cornelia G. van Helden-Meeuwsen, Pieter J. M. Leenen, Nico van Rooijen, Nisar A. Khan, Rebecca C. M. Kiekens, Robbert Benner, and Marjan A. Versnel Chorionic gonadotropin alleviates thioglycollate-induced peritonitis by affecting macrophage function hCG contributes to the controlled inflammatory state of pregnancy by regulating M pro-inflammatory function. J Leukoc Biol 2009 86: 361–370 . [Abstract] [Full Text] [PDF]

María Virginia Tribulatti, Valentina Cattaneo, Ulf Hellman, Juan Mucci, and Oscar Campetella Galectin-8 provides costimulatory and proliferative signals to T lymphocytes CD4+ T cells are the main lymphocyte target of Galectin-8, which lowers their activation threshold and thus suggesting the lectin involvement in inflammatory diseases. J Leukoc Biol 2009 86: 371–380 . [Abstract] [Full Text] [PDF]

Annika Asplund, Gunnel Östergren-Lundén, Germán Camejo, Pia Stillemark-Billton, and Göran Bondjers Hypoxia increases macrophage motility, possibly by decreasing the heparan sulfate proteoglycan biosynthesis Hypoxia-induced modifications of HSPG may be of relevance for the development of atherosclerotic lesions and tumor progression. J Leukoc Biol 2009 86: 381–388 . [Abstract] [Full Text] [PDF]

Sabine C. Lindner, Ulrike Köhl, Thorsten J. Maier, Dieter Steinhilber, and Bernd L. Sorg TLR2 ligands augment cPLA2 activity and lead to enhanced leukotriene release in human monocytes Increased synthesis of inflammatory eicosanoids can be primed by innate immune receptor activation. J Leukoc Biol 2009 86: 389–399 . [Abstract] [Full Text] [PDF]

Jihong Xu, Gail Wagoner, James C. Douglas, and Paul D. Drew Liver X receptor agonist regulation of Th17 lymphocyte function in autoimmunity LXR agonists alter Th17 cell function and suppress EAE. J Leukoc Biol 2009 86: 401–409 . [Abstract] [Full Text] [PDF]

Andrew J. Fleetwood, Hang Dinh, Andrew D. Cook, Paul J Hertzog, and John A. Hamilton GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on Type I interferon signaling Type I IFN differentially regulates the phenotype, function and polarization of particular macrophage populations. J Leukoc Biol 2009 86: 411–421 . [Abstract] [Full Text] [PDF] [Supplemental Figures 1 & 2]

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Host Defense & Pathophysiology

Anke Osterloh, Frank Geisinger, Melanie Piédavent, Bernhard Fleischer, Norbert Brattig, and Minka Breloer Heat shock protein 60 (HSP60) stimulates neutrophil effector functions HSP60 functions as a chemoattractant and activator of neutrophil granulocytes. J Leukoc Biol 2009 86: 423–434 . [Abstract] [Full Text] [PDF]

Consuelo Ortega, Silvia Fernández-A, Juan M. Carrillo, Pilar Romero, Ignacio J. Molina, José C. Moreno, and Manuel Santamaría IL-17-producing CD8+ T lymphocytes from psoriasis skin plaques are cytotoxic effector cells that secrete Th17-related cytokines Lytic CD8+ T cells at the psoriasis plaque’s epidermis secrete IL-17, IL-21 and IL-22 and depends on autocrine TNFalpha production. J Leukoc Biol 2009 86: 435–443 . [Abstract] [Full Text] [PDF]

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Systems Biology & Immunogenetics

Olga Ostrovsky, Michael Korostishevsky, Itay Shafat, Margarita Mayorov, Neta Ilan, Israel Vlodavsky, and Arnon Nagler Inverse correlation between HPSE gene single nucleotide polymorphisms and heparanase expression: possibility of multiple levels of heparanase regulation Combination of two HPSE gene single nucleotide polymorphisms predicts heparanase expression levels and possibly disease outcome. J Leukoc Biol 2009 86: 445–455 . [Abstract] [Full Text] [PDF] [Supplemental Tables 1-3]

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Consulting Editors

CONSULTING EDITORS J Leukoc Biol 2009 86: 457–459 . [Full Text] [PDF]

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.