Other Issues:	Contents: September 2009, Volume 86, Issue 3   [Index by Author]  [Cover Caption] Editorials Pivotal Advance Spotlight on Leading Edge Research Reviews Overviews Primary Research Cell Development, Differentiation, & Trafficking Receptors, Signal Transduction, & Genes Inflammation, Extracellular Mediators, & Effector Molecules Host Defense & Pathophysiology
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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF)

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Editorials

Vincent Jaquet and Karen Bedard Editorial: Genetic mapping—the path of discovery for novel functions of the NOX NADPH oxidases Discussion of the genetic basis of eosinophilia found in the Matsumoto Eosinophilia Shinshu (MES) leading to a role for p22phox, a necessary subunit of several NOX NADPH oxidase enzymes. J Leukoc Biol 2009 86: 461–463 . [Full Text] [PDF]

Claudio Sorio and Paola Melotti Editorial: The role of macrophages and their scavenger receptors in cystic fibrosis Alterations in the capability of CF lung macrophage to respond and clear airway pathogens might contribute to the development of lung disease in cystic fibrosis. J Leukoc Biol 2009 86: 465–468 . [Full Text] [PDF]

Siobhán C. Cowley Editorial: Proinflammatory cytokines in pneumonic tularemia: too much too late? Accumulating evidence indicates that the early initial immunosuppression of pneumonic tularemia is followed by a later overwhelming up-regulation of pro-inflammatory cytokines that is detrimental to the host. J Leukoc Biol 2009 86: 469–470 . [Full Text] [PDF]

Marco E. Bianchi Editorial: A recipe for inflammation Many injectable protein preparations are contaminated with AGEs, post-translationally modified proteins that elicit inflammation and are therefore dangerous. J Leukoc Biol 2009 86: 471–472 . [Full Text] [PDF]

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Pivotal Advance

Masayuki Mori, Guixin Li, Maiko Hashimoto, Ayako Nishio, Hiroshi Tomozawa, Nobuyoshi Suzuki, Shin-ichi Usami, Keiichi Higuchi, and Kiyoshi Matsumoto Pivotal Advance: Eosinophilia in the MES rat strain is caused by a loss-of-function mutation in the gene for cytochrome b(-245), alpha polypeptide (Cyba) NADPH oxidase plays a role in homeostatic regulation of innate immunity beyond conventional microbicidial functions. J Leukoc Biol 2009 86: 473–478 . [Abstract] [Full Text] [PDF]

Adam K. A. Wright, Satish Rao, Simon Range, Christiane Eder, Thomas P. J. Hofer, Marion Frankenberger, Lester Kobzik, Chris Brightling, Jonathan Grigg, and Loems Ziegler-Heitbrock Pivotal Advance: Expansion of small sputum macrophages in CF: failure to express MARCO and mannose receptors In the airways of classical CF cases there is a high number of newly immigrated small macrophages, which are disabled with respect to scavenger receptor-mediated phagocytosis. J Leukoc Biol 2009 86: 479–489 . [Abstract] [Full Text] [PDF]

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Spotlight on Leading Edge Research

Jyotika Sharma, Qun Li, Bibhuti B. Mishra, Christopher Pena, and Judy M. Teale Lethal pulmonary infection with Francisella novicida is associated with severe sepsis Excessive host inflammatory responses negatively impact the disease outcome in pneumonic tularemia. J Leukoc Biol 2009 86: 491–504 . [Abstract] [Full Text] [PDF] [Supplemental Figures 1 & 2; Table 1]

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Reviews

Ravichandran Ramasamy, Shi Fang Yan, and Ann Marie Schmidt RAGE: therapeutic target and biomarker of the inflammatory response—the evidence mounts RAGE may be a biomarker and/or target for therapeutic intervention in chronic disease such as diabetes, inflammation, neurodegeneration, and tumors. J Leukoc Biol 2009 86: 505–512 . [Abstract] [Full Text] [PDF]

Bin Gao, Svetlana Radaeva, and Ogyi Park Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases Liver natural killer and natural killer T cells not only play a critical role in anti-viral and anti-tumor defenses but also contribute to the pathogenesis of chronic liver diseases. J Leukoc Biol 2009 86: 513–528 . [Abstract] [Full Text] [PDF]

RoseMarie Stillie, Shukkur Muhammed Farooq, John R. Gordon, and Andrew W. Stadnyk The functional significance behind expressing two IL-8 receptor types on PMN The presence of two CXCL8 receptor types combined with the inflammatory roles of PMN has led to interest in whether each receptor type contributes to unique functions. J Leukoc Biol 2009 86: 529–543 . [Abstract] [Full Text] [PDF]

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Overviews

Stephen Hatfield, Bryan Belikoff, Dmitriy Lukashev, Michail Sitkovsky, and Akio Ohta The antihypoxia-adenosinergic pathogenesis as a result of collateral damage by overactive immune cells The consumption of natural A2A adenosine receptor antagonists, such as caffeine, as well as the use of supplemental oxygen during acute inflammation episodes may have undesirable effects. J Leukoc Biol 2009 86: 545–548 . [Abstract] [Full Text] [PDF]

Sonia Carta, Patrizia Castellani, Laura Delfino, Sara Tassi, Roberta Venè, and Anna Rubartelli DAMPs and inflammatory processes: the role of redox in the different outcomes Extracellular redox changes are relevant to the start, progress, and resolution of different acute or chronic inflammatory processes, with emphasis on the modulation of DAMP activity. J Leukoc Biol 2009 86: 549–555 . [Abstract] [Full Text] [PDF]

Jan M. Ehrchen, Cord Sunderkötter, Dirk Foell, Thomas Vogl, and Johannes Roth The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer S100A8 and S100A9 are novel members of the group of damage-associated molecular pattern molecules (DAMP) which are early amplifiers of innate immune responses to tissue damage or danger signals. J Leukoc Biol 2009 86: 557–566 . [Abstract] [Full Text] [PDF]

Paul L. Bollyky, Ben A. Falk, Rebecca P. Wu, Jane H. Buckner, Thomas N. Wight, and Gerald T. Nepom Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells The authors describe the immunoregulatory contributions of intact versus fragmented hyaluronan, a prominent component of the extracellular matrix. J Leukoc Biol 2009 86: 567–572 . [Abstract] [Full Text] [PDF] [Supplemental Materials and Methods]

Marco E. Bianchi HMGB1 loves company HMGB1 outside of a cell is both a trigger of inflammation and a stimulus for tissue reconstruction; the balance may depend on the complexes it forms with other molecules. J Leukoc Biol 2009 86: 573–576 . [Abstract] [Full Text] [PDF]

Su Yin Lim, Mark J. Raftery, Jesse Goyette, Kenneth Hsu, and Carolyn L. Geczy Oxidative modifications of S100 proteins: functional regulation by redox Alterations in the capability of CF lung macrophage to respond and clear airway pathogens might contribute to the development of lung disease in cystic fibrosis. J Leukoc Biol 2009 86: 577–587 . [Abstract] [Full Text] [PDF]

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Primary Research

Per M. Humpert, Ivan K. Lukic, Suzanne R. Thorpe, Stefan Hofer, Ezzat M. Awad, Martin Andrassy, Elizabeth K. Deemer, Michael Kasper, Erwin Schleicher, Markus Schwaninger, Markus A. Weigand, Peter P. Nawroth, and Angelika Bierhaus AGE-modified albumin containing infusion solutions boosts septicaemia and inflammation in experimental peritonitis Advanced glycation endproducts (AGEs) act as potential contaminants of infusion solutions boosting inflammation in experimental sepsis. J Leukoc Biol 2009 86: 589–597 . [Abstract] [Full Text] [PDF]

Xiaoyan Liang, Antonio Romo de Vivar Chavez, Nicole E. Schapiro, Patricia Loughran, Stephen H. Thorne, Andrew A. Amoscato, Herbert J. Zeh, Donna Beer-Stolz, Michael T. Lotze, and Michael E. de Vera Ethyl pyruvate administration inhibits hepatic tumor growth The first demonstration of ethyl pyruvate inhibition of liver tumor growth associated with induction of tumor apoptosis, diminished HMGB1 release, and decreased inflammation is reported. J Leukoc Biol 2009 86: 599–607 . [Abstract] [Full Text] [PDF]

Lara Campana, Lidia Bosurgi, Marco E. Bianchi, Angelo A. Manfredi, and Patrizia Rovere-Querini Requirement of HMGB1 for stromal cell-derived factor-1/CXCL12-dependent migration of macrophages and dendritic cells Alterations in the capability of CF lung macrophage to respond and clear airway pathogens might contribute to the development of lung disease in cystic fibrosis. J Leukoc Biol 2009 86: 609–615 . [Abstract] [Full Text] [PDF]

Roberta Palumbo, Francesco De Marchis, Tobias Pusterla, Antonio Conti, Massimo Alessio, and Marco E. Bianchi Src family kinases are necessary for cell migration induced by extracellular HMGB1 The signaling pathways activated by extracellular HMGB1 to mediate cell migration include Src and related kinases, which target cystoskeletal proteins directly. J Leukoc Biol 2009 86: 617–623 . [Abstract] [Full Text] [PDF]

Pinhua Pan, Jon Cardinal, Rajeev Dhupar, Matthew R. Rosengart, Michael T. Lotze, David A. Geller, Timothy R. Billiar, and Allan Tsung Low-dose cisplatin administration in murine cecal ligation and puncture prevents the systemic release of HMGB1 and attenuates lethality Platinating agents in general, and cisplatin specifically, may be a novel candidate approach to the treatment of sepsis. J Leukoc Biol 2009 86: 625–632 . [Abstract] [Full Text] [PDF]

Shaival H. Davé, Jeremy S. Tilstra, Katsuyoshi Matsuoka, Fengling Li, Richard A. DeMarco, Donna Beer-Stolz, Antonia R. Sepulveda, Mitchell P. Fink, Michael T. Lotze, and Scott E. Plevy Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis In two murine models of the human inflammatory bowel diseases, treatment with ethyl pyruvate ameliorated multiple features of active colitis, possibly by inhibiting expression and release of the damage-associated molecular pattern molecule HMGB1 from inflamed intestinal mucosa. J Leukoc Biol 2009 86: 633–643 . [Abstract] [Full Text] [PDF]

Yuko Nawa, Ko-ichi Kawahara, Salunya Tancharoen, Xiaojie Meng, Hisayo Sameshima, Takashi Ito, Yoshiki Masuda, Hitoshi Imaizumi, Teruto Hashiguchi, and Ikuro Maruyama Nucleophosmin may act as an alarmin: implications for severe sepsis Nucleophosmin exerts potent biological activities that contribute to systemic inflammation. J Leukoc Biol 2009 86: 645–653 . [Abstract] [Full Text] [PDF]

Hulda Sigridur Hreggvidsdottir, Therese Östberg, Heidi Wähämaa, Hanna Schierbeck, Ann-Charlotte Aveberger, Lena Klevenvall, Karin Palmblad, Lars Ottosson, Ulf Andersson, and Helena Erlandsson Harris The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation A prototypic mechanism for enhancement of inflammation by an endogenous molecule is described. J Leukoc Biol 2009 86: 655–662 . [Abstract] [Full Text] [PDF]

Christoph Coch, Nicolas Busch, Vera Wimmenauer, Evelyn Hartmann, Markus Janke, Mona Mohamed Ahmed Abdel-Mottaleb, Alf Lamprecht, Janos Ludwig, Winfried Barchet, Martin Schlee, and Gunther Hartmann Higher activation of TLR9 in plasmacytoid dendritic cells by microbial DNA compared with self-DNA based on CpG-specific recognition of phosphodiester DNA Mammalian genomic DNA complexed to the natural antimicrobial cationic peptide LL37 induces type I interferon but less than bacterial DNA or CG-dinucleotide containing oligodeoxynucleotides. J Leukoc Biol 2009 86: 663–670 . [Abstract] [Full Text] [PDF]

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Cell Development, Differentiation, & Trafficking

Mieke Gouwy, Sofie Struyf, Hannelien Verbeke, Willy Put, Paul Proost, Ghislain Opdenakker, and Jo Van Damme CC chemokine ligand-2 synergizes with the nonchemokine G protein-coupled receptor ligand fMLP in monocyte chemotaxis, and it cooperates with the TLR ligand LPS via induction of CXCL8 Novel mechanism of enhancing monocyte chemotaxis during bacterial infections with gram-negative bacteria demonstrates the importance of local contexts in inflammatory and infectious insults. J Leukoc Biol 2009 86: 671–680 . [Abstract] [Full Text] [PDF]

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Receptors, Signal Transduction, & Genes

Madhuri Ramanathan, Wenting Luo, Balázs Csóka, György Haskó, Dmitry Lukashev, Michail V. Sitkovsky, and Samuel Joseph Leibovich Differential regulation of HIF-1 isoforms in murine macrophages by TLR4 and adenosine A2A receptor agonists Up-regulation of adenosine A2A receptors (A2ARs) and the HIF-1l. 1 isoform plays an important role in the switch of macrophages from an inflammatory (M1) to an angiogenic (M2-like) phenotype. J Leukoc Biol 2009 86: 681–689 . [Abstract] [Full Text] [PDF]

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Inflammation, Extracellular Mediators, & Effector Molecules

Mi Seon Jang, Young Min Son, Gi Rak Kim, Yeo Jin Lee, Woon Kyu Lee, Seok Ho Cha, Seung Hyun Han, and Cheol-Heui Yun Synergistic production of interleukin-23 by dendritic cells derived from cord blood in response to costimulation with LPS and IL-12 IL-23 secretion from stimulated DCs, dependent on ERK1/2 and p38 MAPK, caused an induction of memory interferon--secreting T cells. J Leukoc Biol 2009 86: 691–699 . [Abstract] [Full Text] [PDF]

Bryce N. Alves, Jeff Leong, David L. Tamang, Viki Elliott, Jillian Edelnant, Doug Redelman, Cherie A. Singer, Andrew R. Kuhn, Rita Miller, Mark E. Lowe, and Dorothy Hudig Pancreatic lipase-related protein 2 (PLRP2) induction by IL-4 in cytotoxic T lymphocytes (CTLs) and reevaluation of the negative effects of its gene ablation on cytotoxicity Ablation of the gene for the lipase PLRP2 reduces perforin-dependent CTL cytotoxicity, even under conditions when PLRP2 is unexpressed, raising serious doubts about PLRP2s function in cytotoxicity. J Leukoc Biol 2009 86: 701–712 . [Abstract] [Full Text] [PDF] [Supplemental Figure 1]

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Host Defense & Pathophysiology

Hillarie Plessner Windish, P. Ling Lin, Joshua T. Mattila, Angela M. Green, Ezenwa Obi Onuoha, Lawrence P. Kane, and JoAnne L. Flynn Aberrant TGF-β signaling reduces T regulatory cells in ICAM-1-deficient mice, increasing the inflammatory response to Mycobacterium tuberculosis Uncontrolled lung pathology resulting from reduced T regulatory cells causes increased susceptibility to Mycobacterium tuberculosis in ICAM-1-deficient mice. J Leukoc Biol 2009 86: 713–725 . [Abstract] [Full Text] [PDF] [Supplemental Figures 1 & 2]

Michael E. Woodman, Anne E. Cooley, Rita Avdiushko, Amy Bowman, Marina Botto, R. Mark Wooten, Nico van Rooijen, Donald A. Cohen, and Brian Stevenson Roles for phagocytic cells and complement in controlling relapsing fever infection Macrophages and/or dendritic cells were found to play significant roles in both antibody-dependent and -independent control of B. hermsii infection, while bacterial binding of host factor H was found to be nonessential. J Leukoc Biol 2009 86: 727–736 . [Abstract] [Full Text] [PDF] [Supplemental Figures 1-5]

Natsuko Nakamura, Motohiro Nonaka, Bruce Yong Ma, Shogo Matsumoto, Nobuko Kawasaki, Shinji Asano, and Toshisuke Kawasaki Characterization of the interaction between serum mannan-binding protein and nucleic acid ligands Serum C-type lectin MBP is shown to bind DNA and RNA from bacteria, plasmids, synthetic oligonucleotides, and fragmented DNA of apoptotic cells via its carbohydrate recognition domain. J Leukoc Biol 2009 86: 737–748 . [Abstract] [Full Text] [PDF]

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.