Journal of Leukocyte Biology -- Table of Contents (October 2009, 86 [4])

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Contents:

October 2009, Volume 86, Issue 4
[Index by Author] [Cover Caption]

Letter to the Editor

Editorials

Spotlight on Leading Edge Research

Reviews

Cell Development, Differentiation, & Trafficking

Receptors, Signal Transduction, & Genes

Inflammation, Extracellular Mediators, & Effector Molecules

Host Defense & Pathophysiology

Translational and Clinical Immunology

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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF)

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Letter to the Editor

Delphine M. Lees and Alan Hall

Memorial: Emmanuelle Caron 1967–2009
J Leukoc Biol 2009 86: 749–750 . [Full Text] [PDF]

Editorials

Jeff J. Subleski and John R. Ortaldo

Editorial: NKT cells: to suppress or not to suppress, that is the question
Potential differences between human and murine NKT cells in shaping an immune response.
J Leukoc Biol 2009 86: 751–752 . [Full Text] [PDF]

Edward F. Knol and Bernhard F. Gibbs

Editorial: Basophil survival and immunomodulatory function are uniquely regulated by a novel MyD88-dependent pathway
Basophils are important gatekeepers in the development of TH2-skewed immune responses.
J Leukoc Biol 2009 86: 753–755 . [Full Text] [PDF]

Spotlight on Leading Edge Research

Subramanya Hegde, Ewa Jankowska-Gan, Drew A. Roenneburg, Jose Torrealba, William J. Burlingham, and Jenny E. Gumperz

Human NKT cells promote monocyte differentiation into suppressive myeloid antigen-presenting cells
A novel pathway by which human NKT cells may promote T cell tolerance.
J Leukoc Biol 2009 86: 757–768 . [Abstract] [Full Text] [PDF] [Supplemental Figures 1-3]

Kelly M. Kroeger, Brandon M. Sullivan, and Richard M. Locksley

IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38 ${alpha}$ -dependent pathway
Signal identified by which basophils express cytokines involved in allergy independent of the more classically studied basophil activation pathway induced by cross-linking of surface IgE receptors.
J Leukoc Biol 2009 86: 769–778 . [Abstract] [Full Text] [PDF] [Supplemental Figures 1-6; Tables 1 & 2]

Reviews

Larissa Herkenhoff Haut and Hildegund C. J. Ertl

Obstacles to the successful development of an efficacious T cell-inducing HIV-1 vaccine
Preclinical and clinical HIV-1 cell vaccine development continues to be hampered by the lack of validated preclinical animal models: a discussion about way forward.
J Leukoc Biol 2009 86: 779–793 . [Abstract] [Full Text] [PDF]

Erika D. Reynoso and Shannon J. Turley

Unconventional antigen-presenting cells in the induction of peripheral CD8⁺ T cell tolerance
This review highlights the role of nonhematopoietic cells in the induction and maintenance of peripheral CD8+ T cell tolerance.
J Leukoc Biol 2009 86: 795–801 . [Abstract] [Full Text] [PDF]

Jodi McGill, Jonathan W. Heusel, and Kevin L. Legge

Innate immune control and regulation of influenza virus infections
This manuscript reviews the current literature on the importance of innate immune cells in the control of influenza virus infections.
J Leukoc Biol 2009 86: 803–812 . [Abstract] [Full Text] [PDF]

Cell Development, Differentiation, & Trafficking

Torsten A. Konrad, Anna Karger, Hubert Hackl, Ilse Schwarzinger, Irene Herbacek, and Rotraud Wieser

Inducible expression of EVI1 in human myeloid cells causes phenotypes consistent with its role in myelodysplastic syndromes
EVI1, a gene involved in myelodysplastic syndromes, causes growth arrest and cell death in U937 cells.
J Leukoc Biol 2009 86: 813–822 . [Abstract] [Full Text] [PDF]

Jihyun Yang, Young Hee Ryu, Cheol-Heui Yun, and Seung Hyun Han

Impaired osteoclastogenesis by staphylococcal lipoteichoic acid through Toll-like receptor 2 with partial involvement of MyD88
Staphylococcal LTA inhibits osteoclast differentiation primarily through TLR2; and in part through MyD88 signaling, which in turn inhibits activation of ERK, JNK, and AP-1.
J Leukoc Biol 2009 86: 823–831 . [Abstract] [Full Text] [PDF]

Receptors, Signal Transduction, & Genes

Ricky Cheung, Mobeen Malik, Vipa Ravyn, Brian Tomkowicz, Andrzej Ptasznik, and Ronald G. Collman

An arrestin-dependent multi-kinase signaling complex mediates MIP-1β/CCL4 signaling and chemotaxis of primary human macrophages
CCR5-triggered chemotaxis in primary human macrophages depends on both G_i ${alpha}$ -dependent pathways and a novel G_i ${alpha}$ -independent mechanism.
J Leukoc Biol 2009 86: 833–845 . [Abstract] [Full Text] [PDF]

M. Grandoch, V. Bujok, D. Fleckenstein, M. Schmidt, J. W. Fischer, and A-A. Weber

Epac inhibits apoptosis of human leukocytes
Selective activation of Epac proteins inhibits apoptosis in U937, HL-60, and primary human mononuclear cells.
J Leukoc Biol 2009 86: 847–849 . [Abstract] [Full Text] [PDF] [Supplemental Figures 1-4]

William M. McKillop, John W. Barrett, Stephen H. Pasternak, Bosco M. C. Chan, and Gregory A. Dekaban

The extracellular domain of CD11d regulates its cell surface expression
CD11d’s extracellular domain is responsible for intracellular retention of the protein to the Golgi apparatus, a restriction which is relieved upon CD11d/CD18 heterodimerization resulting in release of the integrin to the cell surface.
J Leukoc Biol 2009 86: 851–862 . [Abstract] [Full Text] [PDF] [Supplemental Figures 1 & 2]

Wenji Piao, Chang Song, Haiyan Chen, Marco A. Quevedo Diaz, Larry M. Wahl, Katherine A. Fitzgerald, Liwu Li, and Andrei E. Medvedev

Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-β-dependent pathways and increases expression of negative regulators of TLR signaling
Endotoxin tolerance interferes with TLR4 signalosome assembly, kinase/transcription factor activation, and increases negative TLR pathway regulators.
J Leukoc Biol 2009 86: 863–875 . [Abstract] [Full Text] [PDF] [Supplemental Figures 1-3]

Yu-Li Lin, Yu-Chih Liang, Yu-Shan Tseng, Hsin-Yi Huang, Shu-Yu Chou, Ruey-Shyang Hseu, Ching-Tsan Huang, and Bor-Luen Chiang

An immunomodulatory protein, Ling Zhi-8, induced activation and maturation of human monocyte-derived dendritic cells by the NF- ${kappa}$ B and MAPK pathways
Mushroom product induces a Th1 response and may possess a potential effect in regulating immune responses.
J Leukoc Biol 2009 86: 877–889 . [Abstract] [Full Text] [PDF]

Inflammation, Extracellular Mediators, & Effector Molecules

Hsin-Ni Li, Peter G. Barlow, Johan Bylund, Annie Mackellar, Åse Björstad, James Conlon, Pieter S. Hiemstra, Chris Haslett, Mohini Gray, A. John Simpson, Adriano G. Rossi, and Donald J. Davidson

Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages
LL37-induced secondary necrosis of apoptotic neutrophils with release of granule contents potentiates the anti-inflammatory activity of apoptotic neutrophils on macrophages.
J Leukoc Biol 2009 86: 891–902 . [Abstract] [Full Text] [PDF]

Karim Dorgham, Ata Ghadiri, Patricia Hermand, Mathieu Rodero, Lucie Poupel, Mutsumori Iga, Oliver Hartley, Guy Gorochov, Christophe Combadière, and Philippe Deterre

An engineered CX3CR1 antagonist endowed with anti-inflammatory activity
Identification of a chemokine analogue that antagonized CX3CL1-CX3CR1-dependent responses both in vitro and in vivo
J Leukoc Biol 2009 86: 903–911 . [Abstract] [Full Text] [PDF]

Robert J. Kaner, Francisco Santiago, and Ronald G. Crystal

Up-regulation of alveolar macrophage matrix metalloproteinases in HIV1⁺ smokers with early emphysema
Increased production and activation of proteases by alveolar macrophages may contribute to the accelerated destruction of lung tissue in HIV-1⁺ smokers.
J Leukoc Biol 2009 86: 913–922 . [Abstract] [Full Text] [PDF] [Supplemental Figure 1]

Helle Jensen, Lars Andresen, Karen Aagaard Hansen, and Søren Skov

Cell-surface expression of Hsp70 on hematopoietic cancer cells after inhibition of HDAC activity
Chemotherapeutic stress sensitizes cancer cells for immunorecognition by facilitating Hsp70 cell surface expression.
J Leukoc Biol 2009 86: 923–932 . [Abstract] [Full Text] [PDF]

Takahiro Chino, Kevin E. Draves, and Edward A. Clark

Regulation of dendritic cell survival and cytokine production by osteoprotegerin
Osteoprotegerin regulates not only DC survival but also the nature of DC-dependent inflammatory responses.
J Leukoc Biol 2009 86: 933–940 . [Abstract] [Full Text] [PDF]

Pietro Presicce, Stefania Giannelli, Adriano Taddeo, Maria Luisa Villa, and Silvia Della Bella

Human defensins activate monocyte-derived dendritic cells, promote the production of proinflammatory cytokines, and up-regulate the surface expression of CD91
Immunostimulatory properties of defensins on DC promote maturation and proinflammatory response.
J Leukoc Biol 2009 86: 941–948 . [Abstract] [Full Text] [PDF]

Kevin P. Crume, David O'Sullivan, John H. Miller, Peter T. Northcote, and Anne C. La Flamme

Delaying the onset of experimental autoimmune encephalomyelitis with the microtubule-stabilizing compounds, paclitaxel and Peloruside A
Microtubule-stabilizing drugs able to delay the onset of CNS disease in an MS mouse model depends on altering both the lymphoid and myeloid cell compartments.
J Leukoc Biol 2009 86: 949–958 . [Abstract] [Full Text] [PDF]

Aiping Bai, Nonghua Lu, Yuan Guo, Zhanju Liu, Jiang Chen, and Zhikang Peng

All-trans retinoic acid down-regulates inflammatory responses by shifting the Treg/Th17 profile in human ulcerative and murine colitis
All-trans retinoic acid inhibits inflammatory responses of human ulcerative and murine colitis.
J Leukoc Biol 2009 86: 959–969 . [Abstract] [Full Text] [PDF]

Tiffany Moses, Lynn Wagner, and Sherry D. Fleming

TLR4-mediated Cox-2 expression increases intestinal ischemia/reperfusion-induced damage
TLR4 stimulates Cox-2-mediated PGE2 production which is necessary but not sufficient for intestinal ischemia/reperfusion-induced damage and inflammation.
J Leukoc Biol 2009 86: 971–980 . [Abstract] [Full Text] [PDF]

Yanlin Wang, Luping Huang, Maen Abdelrahim, Qingsong Cai, Anh Truong, Roger Bick, Brian Poindexter, and David Sheikh-Hamad

Stanniocalcin-1 suppresses superoxide generation in macrophages through induction of mitochondrial UCP2
Mammalian stanniocalcin-1, a secreted phosphogylcoprotein that targets the mitochondria, suppresses superoxide and may function as an LPS antagonist in macrophages.
J Leukoc Biol 2009 86: 981–988 . [Abstract] [Full Text] [PDF]

Host Defense & Pathophysiology

Célio X. C. Santos, Beatriz S. Stolf, Paulo V. A. Takemoto, Angélica M. Amanso, Lucia R. Lopes, Edna B. Souza, Hiro Goto, and Francisco R. M. Laurindo

Protein disulfide isomerase (PDI) associates with NADPH oxidase and is required for phagocytosis of Leishmania chagasi promastigotes by macrophages
Macrophage infection by Leishmania parasite is prone to oxidative stress in a redox-regulated way by protein disulfide isomerase which is closely associated to NADPH oxidase activity.
J Leukoc Biol 2009 86: 989–998 . [Abstract] [Full Text] [PDF]

Kenji Shigematsu, Akira Asai, Makiko Kobayashi, David N. Herndon, and Fujio Suzuki

Enterococcus faecalis translocation in mice with severe burn injury: a pathogenic role of CCL2 and alternatively activated macrophages (M2aM ${phi}$ and M2cM ${phi}$ )
Early after burn injury, CCL2 converts resident mesenteric lymph node macrophages to M2a and M2c macrophages that decrease host antibacterial innate immunity against sepsis stemming from Enterococcus faecalis
J Leukoc Biol 2009 86: 999–1005 . [Abstract] [Full Text] [PDF]

Translational and Clinical Immunology

Ansu Mammen Noronha, YanMei Liang, Jeremy T. Hetzel, Hatice Hasturk, Alpdogan Kantarci, Arthur Stucchi, Yue Zhang, Barbara S. Nikolajczyk, Francis A. Farraye, and Lisa M. Ganley-Leal

Hyperactivated B cells in human inflammatory bowel disease
B cells from Crohn’s disease and ulcerative colitis patients have the potential to influence inflammation through elevated expression of Toll-like receptor 2 and IL-8.
J Leukoc Biol 2009 86: 1007–1016 . [Abstract] [Full Text] [PDF]