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November 2009, Volume 86, Issue 5

  [Index by Author]  [Cover Caption]
Down Letter to the Editor
Down Editorials
Down Spotlight on Leading Edge Research
Down Reviews
Down Leukocytes: Tissue Interactions, Homeostasis and Host Defense
Down Cell Development, Differentiation, & Trafficking
Down Receptors, Signal Transduction, & Genes
Down Inflammation, Extracellular Mediators, & Effector Molecules
Down Host Defense & Pathophysiology
Down Translational and Clinical Immunology

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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF)
To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

Letter to the EditorBack

Brian Crucian and Clarence Sams
Immune system dysregulation during spaceflight: clinical risk for exploration-class missions
Commentary on review by Gueguinou et al. on immune barriers and clinical risks to humans during prolonged, exploration-class space missions.
J Leukoc Biol 2009 86: 1017–1018 . [Full Text] [PDF]

EditorialsBack

Kent W. Christopherson, II and Alan Landay
Editorial: Liver X receptor {alpha} (LXR{alpha}) as a therapeutic target in chronic lymphocytic leukemia (CLL)
The potential application of LXR agonists as negative regulators of proliferation and survival of B-cells from CLL patients is discussed.
J Leukoc Biol 2009 86: 1019–1021 . [Full Text] [PDF]

Britta Engelhardt
Editorial: PSGL-1—the hidden player in T cell trafficking into the brain in multiple sclerosis?
PSGL-1 may contribute to T cell interaction with the inflamed blood-brain barrier in multiple sclerosis; and therapeutic targeting of PSGL-1 in multiple sclerosis may prove beneficial.
J Leukoc Biol 2009 86: 1023–1025 . [Full Text] [PDF]

Spotlight on Leading Edge ResearchBack

Nathan Guéguinou, Cécile Huin-Schohn, Matthieu Bascove, Jean-Luc Bueb, Eric Tschirhart, Christine Legrand-Frossi, and Jean-Pol Frippiat

Review describes hazards present as humans explore space and focuses on the effects of spaceflight on immunity.
J Leukoc Biol 2009 86: 1027–1038 . [Abstract] [Full Text] [PDF]

René Geyeregger, Medhat Shehata, Maximilian Zeyda, Florian W. Kiefer, Karl M. Stuhlmeier, Edit Porpaczy, Gerhard J. Zlabinger, Ulrich Jäger, and Thomas M. Stulnig

A novel role for Liver X receptors in lymphocytic cells is described with potential application in immunosuppression and anti-leukemia therapy.
J Leukoc Biol 2009 86: 1039–1048 . [Abstract] [Full Text] [PDF] [Supplemental Figure 1]

Bouchaib Bahbouhi, Laureline Berthelot, Ségolène Pettré, Laure Michel, Sandrine Wiertlewski, Babette Weksler, Ignacio-Andres Romero, Florence Miller, Pierre-Olivier Couraud, Sophie Brouard, David-Axel Laplaud, and Jean-Paul Soulillou

Significant alterations in the transmigration capacity of peripheral blood T-lymphocytes found as a feature in multiple sclerosis.
J Leukoc Biol 2009 86: 1049–1063 . [Abstract] [Full Text] [PDF]

ReviewsBack

G. Solinas, G. Germano, A. Mantovani, and P. Allavena

TAM and other myeloid-derived tumor infiltrating cells are reviewed as pivotal players in the tumor microenvironment; implications to anti-cancer therapy are described.
J Leukoc Biol 2009 86: 1065–1073 . [Abstract] [Full Text] [PDF]

Rieneke van de Ven, Ruud Oerlemans, Joost W. van der Heijden, George L. Scheffer, Tanja D. de Gruijl, Gerrit Jansen, and Rik J. Scheper

Review evaluates the possible physiological roles of MDR-related ABC transporters on immune effector cells based on reports on their expression patterns and immune-related substrates.
J Leukoc Biol 2009 86: 1075–1087 . [Abstract] [Full Text] [PDF]

Leukocytes: Tissue Interactions, Homeostasis and Host DefenseBack

Edward Thorp and Ira Tabas

Review on how dangerous atherosclerotic plaques form and the critical role for defective phagocytic clearance (or "efferocytosis") of apoptotic macrophages in these lesions.
J Leukoc Biol 2009 86: 1089–1095 . [Abstract] [Full Text] [PDF]

Darren M. Boé, R. William Vandivier, Ellen L. Burnham, and Marc Moss

Review on alcohol abuse increasing the risk for acute respiratory distress syndrome through alterations in pulmonary function, and implications to potential therapeutic targets.
J Leukoc Biol 2009 86: 1097–1104 . [Abstract] [Full Text] [PDF]

Robert D. Stout, Stephanie K. Watkins, and Jill Suttles

Functionally polarized macrophages in chronic pathologies are highly adaptable cells displaying a functional response to tissue signals, which response can be reprogrammed to therapeutic advantage.
J Leukoc Biol 2009 86: 1105–1109 . [Abstract] [Full Text] [PDF]

Robert M. Strieter, Ellen C. Keeley, Molly A. Hughes, Marie D. Burdick, and Borna Mehrad

Bone marrow-derived fibrocytes review as key cellular players in the promotion of the pathogenesis of variety of fibroproliferative disorders, including pulmonary fibrosis.
J Leukoc Biol 2009 86: 1111–1118 . [Abstract] [Full Text] [PDF]

Alexander Zarbock, Helena Müller, Yoshihiro Kuwano, and Klaus Ley

Review on PSGL-1 effects on signaling in myeloid leukocytes activates following selectin engagement.
J Leukoc Biol 2009 86: 1119–1124 . [Abstract] [Full Text] [PDF]

Katherine A. Radek, Matthew J. Ranzer, and Luisa A. DiPietro

Review on how acute ethanol exposure causes immediate and long-term impairment of wound healing and reduces wound angiogenesis.
J Leukoc Biol 2009 86: 1125–1134 . [Abstract] [Full Text] [PDF]

Jarin Chun and Alice Prince

Review on consequences of TLR2 signaling the activation of Ca2+-dependent proteases (calpains) and link to junctional proteins to facilitate PMN migration into the airway lumen.
J Leukoc Biol 2009 86: 1135–1144 . [Abstract] [Full Text] [PDF]

Tanya A. Miura and Kathryn V. Holmes

Innate immune responses in coronavirus infections of the respiratory tract are analyzed in primary differentiated airway and alveolar epithelial cells.
J Leukoc Biol 2009 86: 1145–1151 . [Abstract] [Full Text] [PDF]

Tessa Bergsbaken and Brad T. Cookson

Review of infected macrophages undergoing pyroptosis as a host-healthy alternative to apoptosis.
J Leukoc Biol 2009 86: 1153–1158 . [Abstract] [Full Text] [PDF]

Naja J. Jann, Mathias Schmaler, Sascha A. Kristian, Katherine A. Radek, Richard L. Gallo, Victor Nizet, Andreas Peschel, and Regine Landmann

Study took advantage of the hyper-susceptible phenotype of S. aureus {Delta}dltA against cationic AMPs to investigate the impact of the murine cathelicidin CRAMP to identify its key site of action in neutrophils.
J Leukoc Biol 2009 86: 1159–1169 . [Abstract] [Full Text] [PDF]

Cell Development, Differentiation, & TraffickingBack

In-Woo Park and Johnny J. He

HIV-1 Nef inhibited transwell and transendothelial migration of T cells toward SDF-1{alpha}.
J Leukoc Biol 2009 86: 1171–1178 . [Abstract] [Full Text] [PDF]

Receptors, Signal Transduction, & GenesBack

Pamela Ehrenfeld, Carola E. Matus, Francisca Pavicic, Cesar Toledo, Francisco Nualart, Carlos B. Gonzalez, Rafael A. Burgos, Kanti D. Bhoola, and Carlos D. Figueroa

Proinflammatory peptides known as kinins activate the human neutrophil and induce the release of its primary and tertiary granules.
J Leukoc Biol 2009 86: 1179–1189 . [Abstract] [Full Text] [PDF]

A. E. Hogg, G. C. Bowick, N. K. Herzog, M. W. Cloyd, and J. J. Endsley

PBMC infected with HIV-1 inhibit cytokine signaling and antimicrobial protein expression in human CD8+ T cells.
J Leukoc Biol 2009 86: 1191–1203 . [Abstract] [Full Text] [PDF]

Inflammation, Extracellular Mediators, & Effector MoleculesBack

Sharrón L. Manuel, Todd D. Schell, Edward Acheampong, Saifur Rahman, Zafar K. Khan, and Pooja Jain

DC function to prime anti-Tax CTL response in presence of HTLV-infected T cells, acute exposure to HTLV virions, or cell-free Tax.
J Leukoc Biol 2009 86: 1205–1216 . [Abstract] [Full Text] [PDF] [Supplemental Figures 1 & 2]

Marianna Kulka, Nobuyuki Fukuishi, and Dean D. Metcalfe

Tissue-resident human mast cells may modulate tissue remodeling by the secretion of angiogenin, a potent angiogenic factor.
J Leukoc Biol 2009 86: 1217–1226 . [Abstract] [Full Text] [PDF]

Jessica Chu, L. Michael Thomas, Simon C. Watkins, Luigi Franchi, Gabriel Núñez, and Russell D. Salter

This study explores the mechanism by which a bacterial toxin induces the secretion of a proinflammatory cytokine from innate immune cells.
J Leukoc Biol 2009 86: 1227–1238 . [Abstract] [Full Text] [PDF]

Host Defense & PathophysiologyBack

Cláudia N. Paiva, Rodrigo T. Figueiredo, Karina Kroll-Palhares, Andrea A. Silva, Jaline C. Silvério, Daniel Gibaldi, Alexandre dos S. Pyrrho, Claudia F. Benjamim, Joseli Lannes-Vieira, and Marcelo T. Bozza

CCL2 controls heart inflammation and parasite burden in Trypanosoma cruzi infection through cell recruitment and activation.
J Leukoc Biol 2009 86: 1239–1246 . [Abstract] [Full Text] [PDF]

Fatoumata B. Sow, Gail R. Alvarez, Ryan P. Gross, Abhay R. Satoskar, Larry S. Schlesinger, Bruce S. Zwilling, and William P. Lafuse

Expression of hepcidin in mouse macrophages is regulated by transcription factors activated by IFN receptors and Toll-like receptors TLR2 and TLR4.
J Leukoc Biol 2009 86: 1247–1258 . [Abstract] [Full Text] [PDF]

Translational and Clinical ImmunologyBack

Edith V. Bowers, Jeffrey J. Horvath, Jennifer E. Bond, George J. Cianciolo, and Salvatore V. Pizzo

{alpha}-2M*-mediated antigen delivery leads to cross-presentation and improved cell-mediated immunity, suggesting that {alpha}-2M* may have applications for vaccines based on weakly immunogenic subunits.
J Leukoc Biol 2009 86: 1259–1268 . [Abstract] [Full Text] [PDF]

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.